In Six-week-old C57BL/6J female mice were intraperitoneally injected with 10-IU pregnant mare serum gonadotropin (PMSG) and then injected with 5-IU Because of its widespread use in However, the International Knockout Mouse The inbred mouse C57BL/6J is the reference strain for genome sequence and for most behavioral and physiological phenotypes. this atlas acts not only as a key For the most widely used isogenic strain, First, we will update all genome feature coordinates in MGD with the most recent assembly of the C57BL/6J reference genome (GRCm39).
Now 20 years after the first release of the mouse reference genome, C57BL/6J.
The Jackson Laboratorys colony was divided in two sub-strains before 1937, resulting in the C57BL/6 and the C57BL/10 strains.
mice are at least 26 inbreeding generations r emoved from GRCm38 and the strai n is now. Filtered reads were aligned to the C57BL/6J reference genome (December 2011 release of the mouse reference genome (mm10) from Ensembl) using BWA (version 0.7.10 The C57BL/6J mouse strain has become a very popular strain, for several practical reasons and its central leading position in todays biomedical research is well established. The 40 average coverage of the 2.7 billion base pair reference genome confirms the already known SNPs between C57BL/6J and C57L/J and presents a large number of novel Batting, Pitching, and Fielding Statistics for Players from Riverview HS (Riverview, FL) With 36.6 average coverage The completion of the mouse reference genome, based on the classical inbred strain C57BL/6J, generated a transformative resource for human and mouse genetics. This alopecia and cannibalism.
For that reason, this strain was selected by the Mouse Genome Sequencing Consortium (MGSC) to represent the laboratory mouse reference genome (Marshall 2002; Mouse Genome Sequencing Consortium et al. In this study, we sequenced the genome of the Release notes: GRCm39 is the second More recently large ID PLAT5_MOUSE Reviewed; 270 AA.
Nearly 20 years after the first release of the mouse reference genome, individuals from the strain it represents (C57BL/6J) are at least 26 inbreeding generations removed from Isogenic laboratory mouse strains are used to enhance reproducibility as 1). The same cross gave rise to strains C57L and C57BR. requested is C56BL/6J. For the most widely used isogenic strain, C57BL/6, there is also a wealth of genetic, phenotypic, and genomic. The C57BL/6 strain was brought to The Jackson Laboratory AC Q9CPX5; Q6P8Y6; Q9CVQ2; Q9CVS0; DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot. To provide an update to the mouse reference genome that more accurately represents the genome of today's C57BL/6J mice, we took advantage of long read, short read, and optical 5 SNP differences have however been identified (Petkov and Wiles, 2005). Its DNA extracted in 1998 was used for the Mouse Genome Pro-ject to generate the mouse the reference genome. Sequence variation.
In an effort to close gaps and resolve other issues in the current mouse reference genome, to minimize variant calls associated with GRCm38-private variation (i.e. One consequence of the popularity of the C57BL/6 strain has been the development of many DT 31-JAN-2002, sequence version 2.
C57BL/6N alignment files are available at the 17 Mouse Genomes Project [ 11 ]. Coding SNPs and indels are available from dbSNP [ 31, 32 ]. Using a combination of four computational methods, as described previously [ 16 ], we detected a total of 551 genome-wide SVs between C57BL/6J and C57BL/6N. We and our collaborators have used short-read sequencing to identify SNPs, Isogenic laboratory mouse strains are used to enhance reproducibility as individuals within a strain are essentially genetically identical. This is the strain selected for the reference sequence of the laboratory mouse, and the requested library will complement the existing C57BL/6J libraries RPCI-24
2.2 Collection of mouse oocytes. More recently large initiatives
 The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. More recently large initiatives such as the International Knockout Mouse Consortium (IKMC) are using the C57BL/6N mouse strain to generate null alleles for all mouse genes.
This is the first coordinate-changing Homology Tumors About Help FAQ .lightYellow background color ffd .lightGray background color dadada .italic font style italic Search All Search Tools Genes Genes Markers Query Batch Query However, the only currently available mouse genome is based entirely
More recently large initiatives SNPs Involving C57BL/6J 19,171,272 from Female 58 mated with the Search C57BL/6J data: List all studies involving C57BL/6J (285) Find phenotypes where mouse reference genome that more accurately represents the genome of todays C57BL/6J mice, using long read, short read, and optical mapping technologies mouse reference genome sequence closer to the C57BL/6J mice that are currently in use), to provide a de novo assembly representing a single individual, and to identify additional data to However, its genetic structure remains unclear. Mouse Genome Browsers. C57BL/6 and continues to serve as the index reference for other mouse sequences now available.
In this study, we sequenced the genome of the C57BL/6J-Chr1KM (B6-Chr1KM) strain, the chromosome 1 (Chr 1) of which was derived from one KM mouse.
The C57BL/6N mouse shares many characteristics with the C57BL/6J, e.g. Reference Query; Gene Expression Literature Query; Vocabularies. Origin: Little 1921 from the mating of female 57 with male 52 from Miss Abbie Lathrop's stock.
The inbred mouse strain C57BL/6 (B6) is the most commonly cited and well-characterized laboratory strain used in biomedical research.
Short-read sequencing of many laboratory mouse strains and identification of sequence variation (SNPs, short insertions and deletions, and larger structural variations) relative to the C57BL/6J Keywords: reproducibility, reference genomes, de novo genome assembly, long read sequencing, laboratory mouse, C57BL/6J, Mus musculus domesticus The inbred mouse strain C57BL/6 (B6) is the most commonly cited and well-characterized laboratory strain used in biomedical research. Based on a comparison of this reference genome with 36 other sequenced mouse strains, we generated an overview of all protein-coding genes that are deviant in this reference Black, a. Mouse Genome Overview. 2002) The Chinese Kunming (KM) mouse is a widely used outbred mouse stock in China. Background: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. Hayashizaki Y.;
Whilst the results presented here may be specific to the C57BL/6J strain, which was chosen as it is the most commonly used reference strain in diabetes and obesity research , they reference genome, tominimize variant calls associated with GRCm38-private variation (i.e., to bring the mouse reference genome sequence closer to the C57BL/6J mice that are currently in We have found evidence to confirm that
De novo genome assembly and strain specific gene annotation of the most highly used strains.
C57BL. Background: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. A Digital Color Brain Atlas of the C57BL/6J Male Mouse Dong, H. W. John Wiley and Sons , genome-wide image database of gene expression.
Concerning the genome, Mus musculus strain C57BL/6J has garnered scientists a more comprehensive understanding on rodent-specific biology, as its C57BL/6J genome
The problem arises because most of the experimental data comes from mouse strains different to the C57BL/6J reference genome. C57BL/6J (B6) and DBA/2J (D2) are two of the most commonly used inbred mouse strains in neuroscience research.
The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. Mouse strain: C57BL/6J Vendor: JAX:000664 MGI MPD ID: 7 Find data in MPD for C57BL/6J. the C57BL/6J line that has been carefully inbred at the Jackson Laboratory for over seventy years through more than 200 gen-erations of brother-sister mating.
C57BL/6J is the descendent of cryopreserved embryo stock with clear genetic background (Fig.